Infectious

100% fatal once symptomatic. Kills 59,000 people/year, mostly in Africa and Asia. Post-exposure prophylaxis exists but is inaccessible to many.

Bacterial infection killing 1.5 million people per year. Drug-resistant TB is a growing crisis. The BCG vaccine is over 100 years old.

Mosquito-borne parasitic disease killing 600,000+ people per year, mostly children under 5 in Africa.

Lifelong viral infection. HSV-1 affects 3.7 billion, HSV-2 affects 491 million. No cure, only suppressive therapy.

Chronic viral liver infection affecting 300 million people. Can cause liver cancer and cirrhosis. Functional cure remains elusive.

Curable viral liver infection, but treatment costs $20,000-$90,000 per course. 58 million chronically infected globally, mostly in low-income countries.

Viral infection destroying the immune system. ART controls but does not cure. 39 million living with HIV, 630,000 deaths/year.