Codeine+CYP2D6 poor metaboliser=NO EFFECTcritical
Warfarin+CYP2C9*3=INCREASED SENSITIVITYmajor
Clopidogrel+CYP2C19*2=REDUCED EFFECTmajor
Simvastatin+SLCO1B1*5=MYOPATHY RISKmajor
Metformin+SLC22A1 reduced function=REDUCED ABSORPTIONmoderate
Abacavir+HLA-B*5701=FATAL HYPERSENSITIVITYcritical
Carbamazepine+HLA-B*1502=STEVENS-JOHNSON SYNDROMEcritical
Tamoxifen+CYP2D6 poor/intermediate metaboliser=REDUCED EFFICACYmajor
Fluorouracil (5-FU)+DPYD deficiency=SEVERE TOXICITYcritical
Azathioprine+TPMT deficiency=BONE MARROW TOXICITYcritical
