Every page, explained.

The complete index of 9,208 diseases tracked by MedicOath, spanning rare diseases, neglected tropical diseases, oncological, neurological, cardiovascular, autoimmune, and more. Each disease page shows linked hypotheses, neglect score, disease burden data, active clinical trials, an AI-generated summary, and a real-time activity feed showing recent research activity.

Search by name or browse by category. Click any disease to see its full page. Watch a disease to get notified when new hypotheses are generated. Use the RSS button to subscribe in your feed reader. The neglect score ranks diseases by the gap between disease burden and research investment.

All 792 AI-generated drug repurposing hypotheses. Each hypothesis proposes an existing approved drug that could treat a disease it was never designed for. Scored across 7 dimensions: confidence, mechanistic plausibility, evidence convergence, novelty, tractability, impact, and cost. Grounded in real PubMed literature with structured evidence links to papers, compounds, and genes.

Browse by confidence score, disease, or type (repurposing, combination, novel target, traditional medicine, biomarker, mechanism extension). Click any hypothesis to see the full detail page with evidence sources, clinical trial links, plain language summary, peer reviews, discussion thread, version history, and embeddable badge. Quick review in 10 seconds or submit a full 7-dimension scored review.

The repurposing prediction registry — timestamped drug→disease candidates from the learned ranker (degree-weighted metapath features + logistic regression over the knowledge graph). Append-only and pre-registered: predictions are committed before outcomes are known, so the hit rate over time is a public, verifiable track record.

Browse by confidence score or filter by disease. Each row is a RANKED PREDICTION, not a validated cure — a high score means the graph structure resembles known treatments, not proven efficacy. Real-world-evidence causal validation is a separate, later signal shown when available.

An interactive knowledge graph showing the relationships between diseases, genes, compounds, pathways, and proteins derived from the MedicOath corpus. Visualises how different entities connect — revealing potential drug repurposing paths that no single researcher could see by reading papers sequentially.

Search for any entity (disease, gene, drug, pathway) to centre the graph on it. Click nodes to expand their connections. Drag to rearrange. Zoom with scroll wheel. The graph highlights shared pathways between diseases — these shared pathways are where repurposing opportunities exist.

Version-controlled medical research studies — the MedGit system. Like GitHub repositories but for medical research. Every study has a full version history with diffs, can be forked to create variations, and is permanently attributed to its authors. Studies link to related hypotheses, datasets, and clinical trials.

Browse existing studies or create a new one. Fork any study to take the research in a new direction. View the version history to see how a study evolved. Every version is timestamped and citable.

The cure pipeline shows every hypothesis grouped by its lifecycle stage: Generated (AI created it) → Under Review (peer reviews in progress) → Promising (3+ positive reviews) → Investigating (claimed by a researcher) → Validated (experimental evidence supports it) → Trial Ready (sufficient evidence for clinical trial design). This is the real-time view of progress toward cures.

Each stage shows a count and the top hypotheses at that level. Click any hypothesis to see its detail page. The pipeline auto-advances based on peer review outcomes and validation checklist completion. Researchers can claim "promising" hypotheses for investigation.

Every MedicOath discovery is permanently timestamped on the Arbitrum L2 blockchain with an IPFS content hash and a Zenodo DOI. This creates a publicly verifiable, dated record that the discovery was made at a specific time — a prior-art disclosure intended to help keep the discovery free for humanity. ProofChain currently has 697 timestamped records (Arbitrum testnet).

Browse all timestamped records. Click any record to see the blockchain transaction hash, IPFS CID, Zenodo DOI, and the full hypothesis content. Verify any record independently using the Arbitrum Sepolia explorer. Download the citation in BibTeX, RIS, or APA format.

Prometheus is the autonomous signal detection engine that scans new PubMed papers daily for drug repurposing signals. When it finds a high-confidence signal, it triggers Layer-6 — an 8-agent deep investigation pipeline (literature synthesis, safety gate, bioinformatics, drug repurposing, experiment design, conflict of interest, ethics review). This page shows all completed discovery runs with their hypotheses, safety assessments, and investigation reports.

Browse completed runs sorted by date or confidence. Click any run to see the full investigation report including all 8 agent outputs. Start a new Prometheus run for any disease. The system runs automatically via daily cron jobs.

The Neglect Score ranks diseases by the gap between their burden on humanity (measured in DALYs, prevalence, mortality) and the research investment they receive. A high neglect score means the disease causes significant suffering but attracts little research funding — these are the diseases MedicOath prioritises. The score is computed daily from real data.

Sort by neglect score, disease burden, or research investment. Click any disease to see its full page with hypotheses. Use "Run Discovery" to trigger a Prometheus investigation for any disease. Filter by category (rare, neurological, oncological, etc.).

Diseases with the most research activity in the last 7 days. Trending is computed from hypothesis generation velocity, peer review submissions, and paper ingestion. Shows which diseases are getting attention right now on the platform.

Browse trending diseases. Click any to see its full page. The trending score updates daily via automated cron.

Real-time global disease outbreak detection. Aggregates alerts from WHO, CDC, ECDC, PAHO, and HealthMap into a single interactive map. Each alert shows severity level, case count, death count, case fatality rate, and affected regions. Defaults to the map view for immediate visual overview.

The map shows all active outbreaks colour-coded by severity (critical/high/moderate/low). Click any marker for details. Filter by severity level or data source. The system ingests new alerts automatically from official sources.

Ranks pharmaceutical companies by their R&D spending relative to disease burden. Reveals which companies invest in profitable diseases vs neglected ones. Shows revenue, R&D budget, pipeline drugs, and the ratio of spending on high-burden vs low-burden diseases.

Sort by any column. Expand a company row to see their full pipeline breakdown. Compare spending patterns across the industry. Share the data — it's CC0 public domain.

Anonymous portal for submitting suppressed safety data, unpublished trial results, or evidence of research misconduct. Submissions are encrypted and reviewed. Verified submissions are published on the platform. No account required — designed to protect the submitter's identity.

Fill in the anonymous submission form. No login required. Describe the safety concern, attach evidence if available, and submit. Verified submissions appear on the suppressed research page.

A home for findings that did not work — failed experiments, null results, and interventions that showed no effect. Negative results are routinely suppressed in traditional publishing, which hides vital evidence and wastes effort repeating dead ends. MedicOath treats them as first-class data.

Browse by disease or intervention. Each entry records what was tried, what happened, and why it matters. Submitting a negative result is as valuable as a positive one.

Surfaces where the evidence disagrees with itself — hypotheses contradicted by Cochrane systematic reviews, claims resting on retracted papers, and conflicting findings across sources. This is the platform auditing its own output in the open.

Review flagged conflicts. Each shows the contradicting source and how the affected hypothesis has been down-weighted. Nothing is hidden — contradictions are shown, not deleted.

Full-text search across all diseases, hypotheses, studies, and papers on MedicOath. Returns results ranked by relevance with links to the matching pages.

Type your query and press Enter. Filter results by type (diseases, hypotheses, papers). Click any result to navigate to its page.

MO is MedicOath's AI assistant. It knows every part of the platform and can answer questions about diseases, hypotheses, the pipeline, how to contribute, and how the technology works. Powered by Claude.

Type your question in natural language. Ask about any disease, drug, hypothesis, or feature. MO can explain complex biomedical concepts in plain English.

Find generic equivalents and biosimilars for any brand-name drug. Shows the active ingredient, available generics, and price comparisons across countries. Helps patients and clinicians find affordable alternatives.

Search by brand name or active ingredient. See all available generic equivalents with prices. Compare costs across countries.

Leaderboard of all MedicOath contributors ranked by reputation score. Shows each contributor's name, role (researcher/patient/funder/citizen), institution, and when they joined. Click any contributor to see their full public profile with activity heatmap, reviews submitted, diseases watched, and API keys.

Browse the leaderboard sorted by reputation. Click any contributor to see their public profile. Your own profile is at /profile (requires sign-in).

Real-time activity feed showing the latest events across the platform: new hypotheses generated, peer reviews submitted, diseases updated, papers ingested. Subscribe via RSS to get updates in your feed reader without visiting the site.

Scroll to see recent activity. Each event links to the relevant page. Subscribe to the RSS feed for your reader. Per-disease RSS feeds are available on each disease page.

Citizen science data contribution. Share your treatment experience, symptoms, and outcomes anonymously to help guide AI hypothesis generation. Your data is stored with differential privacy protections and contributes to the platform's understanding of how diseases affect real patients.

Follow the 5-step form: select your condition, enter diagnosis year, list symptoms and treatments, consent to data sharing. All data is anonymised. No account required.

Community-funded research bounties. Post a bounty for specific research questions you want answered. Fund bounties to increase their reward. Claim bounties by submitting qualifying research.

Browse open bounties sorted by reward amount. Fund a bounty to increase its visibility. Claim a bounty by submitting research that answers the question. Create a new bounty for a question you want investigated.

Disease-specific research funding campaigns. Each campaign funds Prometheus deep investigation runs for a specific disease. See how much has been raised, how many backers have contributed, and what the funding will produce.

Browse campaigns by disease. Click "Support on Ko-fi" to contribute. 100% of donations fund AI compute for hypothesis generation. Track progress on the campaign page.

Submit research contributions to MedicOath. Upload papers, datasets, clinical observations, or negative results. All submissions are attributed to you and become part of the permanent open-access corpus.

Select the type of contribution (paper, dataset, clinical observation, negative result). Fill in the details. Submit. Your contribution is permanently attributed to your MedicOath profile.

The holistic explanation of what MedicOath is: the mission, the live scale of the platform, what makes it different, and the end-to-end journey from a neglected disease to an open, timestamped cure candidate.

Read the overview to understand the whole platform, then jump into any part. New here? Start here.

A complete, plain-language directory of every page on MedicOath — grouped into sections, each destination described with what it is and how to use it. The fastest way to find any part of the platform.

Use the section jump-links at the top, or scroll. Click any card to go straight to that page.

Create and manage API keys for programmatic access to MedicOath data. Keys are scoped to specific permissions (diseases:read, hypotheses:read, studies:write, etc.) with tiered rate limiting (free: 60/min, research: 300/min, institutional: 1000/min). Maximum 10 active keys per account.

Sign in and create a new key. Select your scopes and tier. The raw key is shown once — save it immediately. Use it with Authorization: Bearer header or X-API-Key header. See API Docs for endpoint documentation.

Complete API documentation with examples in Python, JavaScript, and R. Covers all public endpoints: diseases, hypotheses, studies, search, RSS feeds, citations (BibTeX/RIS/APA), badges, clinical trials, and version history. All data is CC0 public domain.

Browse endpoints by category. Copy the example code for your language. All endpoints return JSON. Authentication is optional for read endpoints, required for write operations.

Real-time system status showing the health of all MedicOath services: Supabase (database), Claude AI (hypothesis generation), PubMed (literature search), and pgvector (semantic search). Auto-refreshes every 60 seconds.

Check service status at a glance. Green = operational, amber = degraded, red = down. Click refresh to check immediately. Service descriptions explain what each component does.

Complete technical explanation of how MedicOath works. Covers the hypothesis generation process, scoring methodology, evidence grounding, peer review system, blockchain timestamping, and the cure pipeline. Written for researchers who want to understand the methodology before trusting the output.

Read through the sections or use the table of contents to jump to a specific topic. Each section explains both the what and the why behind the design decisions.

List of all data sources MedicOath ingests from — PubMed and a wide set of multilingual literature, trial registries, and drug/target databases. Shows which are active and how many records have been ingested from each.

Browse the list of configured data sources. See which are active, their refresh schedule, and how many records have been ingested from each.

Download the complete MedicOath dataset. All diseases, hypotheses, studies, and papers available as CSV or JSON. Everything is CC0 public domain — use it for your own research, build on it, redistribute it. No restrictions.

Select the dataset you want (diseases, hypotheses, papers, or all). Choose format (CSV or JSON). Click download. No account required.

Open genomic intelligence — variant analysis, gene-pathway mapping, and pharmacogenomics data. Links genetic variants to drug responses and disease susceptibility, enabling precision medicine approaches to drug repurposing.

Search by gene name, variant ID, or drug. Explore gene-pathway relationships. See which genetic variants influence drug response for specific diseases.

Tracks drugs approaching their patent cliff — the date when the patent expires and generic manufacturers can legally produce the drug. When a patent expires, MedicOath publishes an open manufacturing protocol so any generics manufacturer worldwide can produce the drug at cost.

Browse by expiry date (soonest first) or by drug. Click any drug to see its patent details, manufacturing protocol (if available), and estimated cost-of-production pricing for different countries.

Compares the manufacturing cost of essential medicines against their retail price in different countries. Reveals the markup applied by pharmaceutical companies — often 50-100x the cost of production. Includes generic alternatives where available.

Search by drug name. Sort by markup ratio, country, or price. See the manufacturing cost vs what patients actually pay. Filter by income tier (low/middle/high income countries).

The Trial Graveyard catalogues compounds that were abandoned during development — not because they didn't work, but because the commercial return didn't justify continued investment. Many of these compounds showed efficacy in early trials but were shelved when the target market was deemed too small. They represent potential repurposing opportunities.

Filter by development stage (Phase I/II/III), reason for abandonment, or therapeutic area. Expand any compound to see its trial history and why it was dropped. Click "Related Hypotheses" to see if MedicOath has generated repurposing hypotheses for the compound.

AI-powered symptom checker. Describe your symptoms in natural language and receive a differential diagnosis ranked by probability. Includes links to relevant MedicOath disease pages and active clinical trials. Not a substitute for medical advice.

Describe your symptoms in the text box. Click Analyse. Review the differential diagnosis. Click any suggested condition to see its MedicOath page with hypotheses and trials. Always consult a healthcare provider.

Tracks global medicine shortages and supply chain disruptions. Shows which essential medicines are currently unavailable or in limited supply, which countries are affected, and what alternatives exist.

Filter by region, drug, or severity. See which medicines are affected and for how long. Find alternative treatments where available.

Educational modules explaining neglected diseases, drug repurposing, clinical trial design, and open science. Designed for non-specialists who want to understand the science behind MedicOath.

Pick a module and work through it at your own pace. Each module includes explanations, examples, and links to relevant MedicOath data.